ea0059p100 | Diabetes & cardiovascular | SFEBES2018
Petursdottir Megan
, Brain Eleanor
, Buckley Charlotte
, Chapman Karen
, Ivy Jessica
During early life, the majority of cardiomyocytes exit the cell cycle and undergo terminal differentiation, becoming binucleated. This establishes the number of cardiomyocytes for the remainder of the lifetime, with subsequent consequences for cardiac resilience in adulthood. Activation of the glucocorticoid receptor (GR) is important for heart maturation: fetal mice lacking GR in cardiomyocytes (SMGRKO) show structural and functional cardiac immaturity. Young adult male and f...